R. Timothy Miller, Assistant Professor - Publications

Miller, R.T., Lau, S.S., Monks, T.J., Metabolism of 5-(Glutathion-S-yl)-a-methyldopamine Following Intracerebroventricular Administration to Male Sprague-Dawley Rats.Chem. Res. Toxicol. 8, 634-641, 1995.

Miller, R.T., Lau, S.S., Monks, T.J., Effects of Intracerebroventricular Administration of 5-(Glutathion-S-yl)-a-methyldopamine on Brain Dopamine, Serotonin and Norepinephrine Concentrations in Male Sprague-Dawley Rats., Chem. Res. Toxicol. 9, 457-465, 1996.

Fitzmaurice, P.S., Shaw, I.C., Kleiner, H.E., Miller, R.T., Monks, T.J., Lau, S.S., Mitchell, J.D. and Lynch, P. G., Evidence for DNA Damage in Amyotrophic Lateral Sclerosis. Muscle and Nerve. 19, 797-798, 1996.

Miller, R.T., Lau, S.S. and Monks, T.J., 2,5-bis-(Glutathion-S-yl)-a-methyldopamine, A Putitive Metabolite of (+)-3,4-Methylenedioxyamphetamine, Decreases Brain Serotonin Concentrations. Eur. J. Pharmacol. 323, 173-180, 1997.

Miller, R.T., Martásek, P., Roman, L.J., Nishimura, J.S., and Masters, B.S.S., Involvement of the Reductase Domain of Neuronal Nitric Oxide Synthase in Superoxide Anion Production. Biochemistry 36, 15277-15284, 1997.

Martásek, P., Miller, R.T., Liu, Q., Roman, L.J., Salerno, J.C., Migita, C.T., Gross, S.S., Ikeda-Saito, M., and Masters, B.S.S., The Cys331Ala Mutant of nNOS is Defective in Arginine Binding. J. Biol. Chem. 27, 34799-34805, 1998.

Martásek, P., Miller, R.T., Roman, L.J., Shea, T., and Masters, B.S.S. Assay of Isoforms of E.coli-Expressed Nitric Oxide Synthases. Methods Enzymol. 301, 70-78, 1998.

Nishimura, J.S. Narayanasami, R., Miller, R.T., Roman, L.J., Panda, S., and Masters, B.S.S. The Stimulatory Effects of Hofmeister Ions on the Activities of Neuronal Nitric Oxide Synthase. Substrate Inhibition by L-Arginine is Overcome in the Presence of Protein Destabilizing Agents. J. Biol. Chem. 274, 5399-5406,1999.

Miller, R.T., Martásek, P., Raman, C.S., and Masters, B.S.S., Zinc Content of E. coli-Expressed Constitutive Isoforms of Nitric Oxide Synthase: Enzymatic Activity and Effect of Pterin. J. Biol. Chem. 274, 14537-14540, 1999.

Miller, R.T., Martásek, P., Omura, T., and Masters, B.S.S. Rapid Kinetic Studies of Electron Transfer in the Three Isoforms of Nitric Oxide Synthase. Biochem. Biophys. Res. Comm. 265, 184-188,1999.

Miller, R.T., Martásek, P, Nishimura, J.S., Panda, S., Harris, D., Roman, L.J., Kim, J-J.P., and Masters, B.S.S. The Flavoprotein Domains of Nitric Oxide Synthase Isoforms: Site of Possible Regulatory Control of Flavin to Heme Electron Transfer. in Flavins and Flavoproteins 1999; Proceedings of the Thirteenth International Symposium, Konstanz, Germany, August 29-September 4, 1999, (R. Weber, ed.) Agency for Scientific Publications, Berlin.

Masters, B.S.S., Miller, R.T., Martásek, P., Roman, L.J., Nishimura, J.S., Panda, S., Harris, D., Shea, T.M., Salerno, J.C., Kim, J-J.P., and Masters, B.S.S. Structural Aspects of the Flavoprotein Domains of Isoforms of Nitric Oxide Synthase. in Flavins and Flavoproteins 1999; Konstanz, Germany, August 29-September 4, 1999, (R. Weber, ed.) Agency for Scientific Publications, Berlin.

Roman, L.J., Miller, R.T., de la Garza, M.A., Kim, J.-J.P., Masters, B.S.S. The C Terminus of Mouse Macrophage Inducible Nitric-oxide Synthase Attenuates Electron Flow through the Flavin Domain. J. Biol. Chem. 275, 21914-21919, 2000.

Roman, L.J., Martasek, P., Miller, R.T., Harris, D.E., de la Garza, M.A., Shea, T.M., Kim, J-J. P., and Masters, B.S.S. The C Termini of Constitutive Nitric-oxide Synthases Control Electron Flow Through the Flavin and Heme Domains and Affect Modulation by Calmodulin. J. Biol. Chem. 275, 29225-29232, 2000.

Loughran, P.A., Roman, L.J., Aitken, A.E., Miller, R.T., and Masters, B.S.S. Identification of Unique Amino Acids that Modulate CYP4A7 Activity. Biochemistry 39, 15110-15120, 2000.

Loughran, P.A., Roman, L.J., Miller, R.T., and Masters, B.S.S. The Kinetic and Spectral Characterization of the E. coli-Expressed Mammalian CYP4A7: Cytochrome b5 Effects Vary with Substrate. Arch. Biochem. Biophys. 385, 311-321, 2001.

Miller, R.T. and Hinck, A.P Characterization of Hydride Transfer to FAD in Neuronal Nitric Oxide Synthase Reductase Domain: Geometric Relationship Between the Nicotinamide and Isoalloxazine Rings. Arch. Biochem. Biophys. 395, 129-135, 2001.

Miller, R.T. Dinitrobenzene-Mediated Production of Peroxynitrite by Neuronal Nitric Oxide Synthase. Chem. Res. Toxicol. 15, 927-934, 2002.

Miller, R.T. Effects of NOx and R-NOx on Drug Metabolism. Current Drug Metabolism 5, 535-542, 2004.